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Fig. 2 | Experimental Hematology & Oncology

Fig. 2

From: Hypoxia-associated circPRDM4 promotes immune escape via HIF-1α regulation of PD-L1 in hepatocellular carcinoma

Fig. 2

Upregulation of circPRDM4 is related to anti-PD-1 therapy response in HCC patients. A Representative radiographic results showing the tumor diameter change pre- and post-immunotherapy in responders and nonresponders. B Expression levels of circPRDM4 in tumor tissues from nonresponders and responders. C Difference in tumor diameter for all included patients. D Quantitative correlation between the change in tumor diameter and circPRDM4 expression level. E Representative immunofluorescence images showing CD8+ cells in tumors of the circPRDM4 high and circPRDM4 low groups. F Correlation analysis between circPRDM4 expression level and CD274 mRNA level in HCC tissues. G Kaplan–Meier survival curves of the included patients’ PFS. H Kaplan–Meier survival curves of the included patients’ OS. Data are shown as mean ± SEM. *, P < 0.05; **, P < 0.01

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