Fig. 8

The expression levels of IL-6, TNF-α and IL-1β in liver, spleen, lung and kidney. We constructed CLP models in WT + CLP, WT + DNase I + CLP and GPR109A^−/− + CLP groups respectively, and collected the liver, spleen, lung and kidney of mice after 3 days. NT means no treatment, Shame means Only surgery was performed without puncture or ligation of the cecum, CLP means cecal puncture and ligation were performed, DNase I + CLP means Cecal puncture and ligation were performed and DNase I was injected. a–c Expression levels of IL-6, TNF-α and IL-1β in lung. d–f Expression levels of IL-6, TNF-α and IL-1β in liver. (g–i) Expression levels of IL-6, TNF-α and IL-1β in kidney. j–l Expression levels of IL-6, TNF-α and IL-1β in spleen. Values are presented as means ± SEM (n = 10) (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001)