Fig. 1

CD26^low and CD26^high CD8⁺ T cells are reduced in CLL. A Representative flow cytometry plots, and (B) Cumulative data comparing the frequency of CD26⁺CD8⁺ T cells in PBMCs from HCs (n = 44) and CLL (n = 55) patients. C Cumulative data comparing the frequency of CD26^low and CD26^high CD8⁺ T cells in HC and CLL. D Bar plots illustrating the proportion of CD26^neg, CD26^low and CD26^highCD8⁺ T cells in HC and CLL (E) Representative histogram plots, and (F) Cumulative data comparing the Mean Fluorescence Intensity (MFI) of CD26 in CD8⁺ T cells in HCs and CLLs. G The pie charts represent the median frequency of CD26^neg/low/high in different subsets of CD8⁺ T cells (e.g. Naïve, Stem cell memory, Central memory, Transitional memory, Effector memory, and Effector) in HCs versus CLLs. H Representative flow cytometry plots of CD26^low/high in different CD8⁺ T cell subsets of HCs (black) and CLLs (red). I Cumulative data of CD26^low/high in naïve, (J) stem cell memory, (K) central memory, (L) transitional memory, (M) effector memory, and (N) effector CD8⁺ T cells in HC and CLL. Statistics are assessed by Mann–Whitney or the Kruskal–Wallis multiple comparison tests. P-value < 0.05 was considered as significant. Error bars represent the median with an interquartile range. Each dot represents an individual human sample