Fig. 2

Characterization of T-ALL patients with a low circFBXW7 expression level. A Enrichment analysis of the custom signature defined by genes upregulated in T-ALL cases with low compared with cases with high circFBXW7 expression (Log Fold Change, LFC > 0.2) among the genes differentially expressed upon circFBXW7 silencing in RPMI-8402. The leading-edge subset of core genes driving the former custom enrichment was, in turn, enriched in specific MSigDB Hallmark gene sets, as shown in the bar plot in the bottom. B Scatterplots of LFC values of 274 genes significantly differentially expressed upon circFBXW7 silencing in the RPMI-8402 cell line and concordantly varied in both patient cohorts, comparing T-ALL cases with low against T-ALL with high circFBXW7 expression (up- and down-regulated genes are shown as red and green dots in separate panels) and C clustering of the functional categories most enriched among genes upregulated upon silencing in vitro and in T-ALL cases with low compared against T-ALL with high circFBXW7 expression