Fig. 4From: Caspase-8 contributes to an immuno-hot microenvironment by promoting phagocytosis via an ecto-calreticulin-dependent mechanismCASP8 expression was related to response to ICB in human cancers. a Heatmap of the expression of 18 genes in the T cell-inflamed gene set in four ICB-treated datasets. b CASP8 transcription level in responders and non-responders. c The response rate in CASP8-high and CASP8-low patients. d Forest plot of the hazard ratio for overall survival. The responders included patients with stable disease for more than 6Â months, complete response, and partial response according to the Response Evaluation Criteria in Solid Tumors (RECIST 1.1). CASP8 expression lower than the median of each cohort was regarded as CASP8-low; otherwise, expression was regarded as CASP8-highBack to article page