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Fig. 2 | Experimental Hematology & Oncology

Fig. 2

From: The emerging scenario of immunotherapy for T-cell Acute Lymphoblastic Leukemia: advances, challenges and future perspectives

Fig. 2

Mechanisms of action of BTCEs. (1) Bivalent BTCEs (bBTCEs), characterized by two arms binding CD3Ɛ (2 + 2 format), re-direct T lymphocytes against T-ALL cells expressing the target antigen. (2) Monovalent BTCEs (mBTCEs), constituted by one arm binding CD3Ɛ (2 + 1 format), empower cytotoxic effect on T-ALL cells compared to bBTCEs and limit T-cell exhaustion

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