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Fig. 4 | Experimental Hematology & Oncology

Fig. 4

From: CDCA8 induced by NF-YA promotes hepatocellular carcinoma progression by regulating the MEK/ERK pathway

Fig. 4

CDCA8 promotes cell migration and invasion of HCC cells in vitro. a Transwell migration assay revealed that CDCA8 overexpression promote the migration capability of PLC/PRF5 cells while CDCA8 inhibition in Bel-7402 cells showed the opposite effect. b Transwell invasion assay revealed that CDCA8 overexpression promoted the invasion capability of PLC/PRF5 cells while CDCA8 knockdown in Huh7 cells exhibited the opposite result. c The expression levels of MAPK pathway related-proteins were assessed after CDCA8 increased or decreased in four HCC cell lines. d, e Representative pictures of (d) migration and (e) invasion assays with or without PD98059 or SCH77298 in HepG2 cells. (**p < 0.01; ***p < 0.001)

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