Table 3 The distribution of cancer spectrum in Cryab transgenic mice
From: Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice
Malignancies | Incidence (frequency) | Features |
|---|---|---|
Hemangiosarcoma | (30%) | This neoplasm was comprised of vascular spaces of varying size, sometimes containing thrombi, and lined by a pleomorphic population of proliferating endothelial cells with frequent mitotic figures present |
Hepatic Carcinoma (hepatocellular carcinoma) | (25%) | There was trabecular growth in irregularly thick plates of neoplastic hepatocytes, which sometimes resembled normal hepatocytes, but often had enlarged, hyperchromatic nuclei, prominent nucleoli, and abundant cytoplasm (megalocytosis) |
Alveolar/Bronchiolar carcinoma | (10%) | In the lung, there was papilliform growth of a pleomorphic population of epithelial cells, which were arranged around a fibrovascular core |
B-cell lymphoma | (10%) | There was effacement of the normal splenic architecture by a proliferating population of CD79a-immunopositive lymphoblastic cells |
Histiocytic sarcoma | (5%) | Tumour was composed of sheets of large, pleomorphic histiocytic cells with abundant cytoplasm; multinucleated giant cells were common |
Metastasis | (20%) | Spleen to liver and lung metastasis, liver (HCC) to lung and liver metastasis |