Fig. 6
From: Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice
Basigin (BSG) inhibition reduces colony formation and cell migration. a colony formation assay (b) transwell migration assay (lower) in E1A/Ras-transformed MEFs, generated from Cryabwt and CryabTg mice, treated with Scr (scrambled) and siRNA (# 6) against BSG. Scale bars, 400 µm, data presented as Mean ± SEM, an average of 3 biological repeats and 3 independent experiments. Student’s t-test was employed for statistical significance, ****P < 0.0001). c The graphical abstract of CryabTg mouse model shows spontaneous tumorigenesis and metastasis in vivo leading to different cancer types such as Hepatocellular carcinoma (HCC), Hemangiosarcoma (HSA), Small lymphocytic lymphoma (SLL), and Adenocarcinoma (AC) due to regulation of several pro-tumorigenic mechanisms including EMT, evasion of apoptosis, angiogenesis and migration (illustrated by BioRender)