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Fig. 5 | Experimental Hematology & Oncology

Fig. 5

From: Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice

Fig. 5

Mass spectrometry (MS)-based proteomics analysis reveales Basigin upregulation in Cryab overexpressed cells. a Biological pathway enrichment analysis of the proteomic data comparing CryabTg E1A/Ras-transformed MEFs to CryabWT MEFs revealed differentially regulated pathways visualized using Cytoscape. Upregulated (red) and downregulated (blue) node proteins in clusters are indicated. b Volcano plot showing up/downregulated proteins (CryabTg/CryabWT) in the proteomic data with corresponding fold changes and p-values. Highlighted BSG had the highest p-value with ~ sevenfold upregulation. c Representative IHC images for comparison of Cryab (high and low expressing areas) and BSG expression in Lymphoma (Lym) liver, adenocarcinoma (ADC) of lung, liver and hepatocellular carcinoma (HCC) of tumour-bearing CryabTg mice, (scale bars, 50 µm). d Correlation (linear regression) between expression of Cryab and Bsg in adenocarcinoma and lymphoma of tumor-bearing CryabTg mice

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