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Table 2 Cox regression analyses of overall survival (OS) in CLL patients

From: CTP synthase 2 predicts inferior survival and mediates DNA damage response via interacting with BRCA1 in chronic lymphocytic leukemia

Variable

 

Univariate analysis

Multivariate analysis

 

HR

95% CI

p value

HR

95% CI

p value

Binet stage

C vs A/B

1.474

0.937–2.389

0.105

   

CTPS2 expression

High vs low

2.745

2.018–3.734

0.001***

0.666

0.416–1.064

0.049*

β2-MG (mg/ L)

 < 3 vs ≥ 3

0.021

0.003–0.126

0.001***

0.001

0.001–0.538

0.876

IGHV status

Unmutated vs mutated

2.923

0.000–87.321

0.844

   

CD38

Positive vs negative

5.279

0.735–37.927

0.098

   

ZAP70

Positive vs negative

21.715

0.109–36.449

0.254

   
  1. Bold font indicates statistical significance
  2. WBC White blood cell; LDH Lactate dehydrogenase; β2-MG β2-microglobulin; HR Hazard ratio; CI Confidence interval
  3. *p < 0.05
  4. ***p < 0.001
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Experimental Hematology & Oncology

ISSN: 2162-3619

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