Table 1 Treatments and survival characteristics of VRL patients
Patient | BTKi treatment (months) | Initial response (1 month) | Complications | Ocular relapse after initial remission (months) | CNS progression | PFS# (months) | OS* (months) | Survival status | Follow-up ꝉ (months) |
|---|---|---|---|---|---|---|---|---|---|
#1 | Z (6) O (3) | CR | No | Bilateral eyes (9.1) | No | 9.1 | 21 + | Alive | 21 |
#2 | Z (4) | CR | Ecchymosis (grade 1) | Bilateral eyes (7.5) | 10 months after BTKi discontinuation | 7.5 | 20 + | Alive | 20 |
#3 | O (18) | CR | Ecchymosis (grade 1) | No | No | 18 + | 18 + | Alive | 18 |
#4 | Z (1) | PD | No | No | 1.2 months since BTKi treatment | 1.2 | 2 | Dead due to CNS progression | 2 |
#5 | O (6) Z (6) | PR | Arthralgia (grade2) Ecchymosis (grade 1) | No | 11.6 months since BTKi treatment | 11.6 | 12 + | Alive | 12 |
#6 | O (9) | CR | No | No | No | 9 + | 9 + | Alive | 9 |
#7 | O (7) | CR | No | No | No | 7 + | 7 + | Alive | 7 |
#8 | I (6) | CR | No | No | No | 6 + | 6 + | Alive | 6 |
#9 | O (3) | PR | No | No | No | 3 + | 3 + | Alive | 3 |
#10 | O (3) | CR | No | No | No | 3 + | 3 + | Alive | 3 |