Fig. 2
From: Immune related biomarkers for cancer metastasis to the brain
Illustration of Brain TIME Immune Biomarkers. Published biomarkers are shown. Red color biomarkers are reported to be negative association with survival in patients with brain metastasis. Blue color biomarkers are the risk factors for brain metastasis. Purple colored are immune suppressive factors associated with favorable outcomes of brain metastasis in patients. Green color biomarkers are proved to enhance the risk of brain metastasis in mouse model. TIME tumor-immune microenvironment, TCR T cell receptor, Foxp3 forkhead box P3, Treg Regulatory T cells, MDSC Myeloid-derived suppressor cells