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Fig. 6 | Experimental Hematology & Oncology

Fig. 6

From: Targeting the integrated stress response in hematologic malignancies

Fig. 6

Differing stress stimuli influence the outcomes of ISR signaling. During homeostasis, normal cells (shown in pink) experience minimal stress and exhibit low ISR signaling. Normal cells can undergo neoplastic transformation to form cancer cells (light purple) which as a consequence of their excessive proliferation and altered metabolism are subject to stimuli such as proteotoxic stress, nutrient restriction and oxidative stress. These chronic stress stimuli trigger a low to moderate level of ISR signaling which can result in a pro-survival feedback response to facilitate cancer cell adaptation to stress. Extrinsic agents that activate the ISR cause a high degree of acute ISR signaling causing the cancer cell to undergo apoptosis. Created with BioRender.com

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