Table 2 Linkers, peptides and targets of some PDCs [139, 159, 160]
Linker | Peptide | |||
|---|---|---|---|---|
Type | Name | Structure | Name | Target |
Non-cleavable | Thioether bond |
| Octreotide | SST2 |
Oxime bond |
| Octreotate | SST2 | |
Triazole bond |
| NGR | CD13 | |
pH sensitive | Hydrazone bond |
| Angiopep-2 | LRP-1 |
Acetal/Ketal bond |
| GnRH | GnRH-R | |
Enzyme sensitive | Ester bond |
| Lys6-modified GnRH | GnRH-R |
Amide bond |
| RGD | αv integrins | |
Carbamate bond |
| c(RGDfK) | αv integrins | |
Val-Cit |
| iRGD | αv integrins | |
Ala-Ala-Asn |
| Bombesin(7–14) | Bombesin receptors | |
Gly-Phe-Leu-Gly |
| TH19P01 | Sortilin receptor | |
Redox sensitive | Ddisulfide bond |
| Bicycle | MMP-14 |
