From: The role of neutrophil extracellular traps in cancer progression, metastasis and therapy
Stimulus | Receptor | Function | Cancer type | References |
---|---|---|---|---|
Cytokines | ||||
CXCL5 | CXCR2 | Promote cancer growth and metastasis by TAN chemotaxis and EMT induction | HCC, LC | |
IL-8 | CXCR1/2 | Promote tumor progression and metastasis by TAN chemotaxis and activation | HCC, LC, CRC, Melanoma | |
IL-6 | CXCR1/2 | Promote cancer growth and metastasis by TAN chemotaxis | HCC, GC | |
IL-17 | IL-17R | Promote cancer growth and metastasis by TAN chemotaxis and activation | HCC, CRC, BC | |
IL-1β | - | Promote tumor progression and metastasis | CRC | [38] |
G-CSF | G-CSFR | Promote cancer growth and metastasis by TAN chemotaxis | LC, BC | |
HMGB1 | TLR4, RAGE | Promote tumor angiogenesis and metastasis by TAN chemotaxis and NETs formation | HCC, CRC, Melanoma | |
TGF-β | TGF-βR | Promote cancer growth by neutrophils N2 phenotype transformation | LC, BC | |
Chemical stimulation | ||||
PMA | PKC | Promote cancer growth and metastasis by NETs formation | LC, BC, PDAC | |
LPS | TLR4 | Promote cancer growth and metastasis by NETs formation | CRC, LC, BC | |
Ca2+ | - | Trigger NETs formation | - | |
Extracellular microbes | ||||
Bacteria, Viruses, Fungi | - | Trigger NETs formation | - |