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Fig. 5 | Experimental Hematology & Oncology

Fig. 5

From: RHO GTPase family in hepatocellular carcinoma

Fig. 5

RHO GTPase-driven cell migration modes. As a response to various signals, migrating cells enter the cell motility cycle. At the leading edge, RAC1 induces the formation of actin-rich lamellipodia. CDC42 determines the formation of filopodia and the direction of motion. New protrusions adhere to the ECM through the formation of focal complexes, which are controlled mainly by RAC1 and RHOA. Then the cell body contracts depending on the formation of stress fibers and the contraction of actin-myosin fibers, which is mediated by RHOA and ROCKs. Finally, the rear adhesions are dissolved, the cell tail retracts, and the cell moves forward

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