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Fig. 5 | Experimental Hematology & Oncology

Fig. 5

From: circRanGAP1/miR-27b-3p/NRAS Axis may promote the progression of hepatocellular Carcinoma

Fig. 5

Prediction of the downstream immune-related target gene of miR-27b-3p in HCC. A. Venn diagram exhibiting miR-27b-3p target mRNAs overlap, estimated by Targetscan, Starbase, miRDB, and miRTarbase databases. B. Overlapped 68 immune-related target genes of miR-27b-3p in 151 predicted targets of miR-27b-3p with the DEGs in the immune and stromal high score group based on the ESTIMATE algorithm. C. The heatmap of 68 immune-related miR-27b-3p target genes. D and E. The top 10 enriched Gene Ontology (GO) and Kyoto Encyclopedia of Genes (KEGG) pathways of 68 immune-related DEGs. F. A circRNA-miRNA-mRNA network of 22 genes associated with the poor prognosis of HCC patients via Cytoscape software. Red: upregulation, Orange: upregulation, Green: downregulation. G. The NRAS and CREB1 expression in tissues effected with HCC compared with matched adjacent normal tissues from the GEPIA database. H. The survival analyses of NRAS and CREB1. *P < 0.05; **P < 0.01; ***P < 0.001; NS not significant

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