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Table 3 Targets of CAR-NK cell-based therapy for solid tumors

From: Chimeric antigen receptor-engineered NK cells: new weapons of cancer immunotherapy with great potential

Target

Tumor

NK cell sources

CAR structures

CAR transfer

Reference

Year

HER2

Breast and Ovarian carcinoma

PB

scFv-CD28-CD3ζ

Retrovirus

[101]

2008

HER2

Breast cancer

NK-92

scFv-CD28-CD3ζ

mRNA electroporation

[102]

2015

HER2

Breast cancer and Renal cell carcinoma

NK-92

scFv‐CD3ζ/scFv-CD28-CD3ζ/scFv-4-1BB-CD3ζ

Lentivirus

[103]

2015

HER2

Glioblastoma

NK-92

scFv-CD28-CD3ζ

Lentivirus

[104]

2016

HER2

Gastric cancer

NK-92

scFv-4-1BB-CD3ζ

Lentivirus

[105]

2019

EGFR/EGFRvIII

Glioblastoma

NK-92/NKL cells/PB

scFv-CD2-CD3ζ

Lentivirus

[76]

2015

EGFR/EGFRvIII

Glioblastoma

NK cell line YTS

scFv-DAP12 + CXCR4

Lentivirus

[106]

2015

EGFR/EGFRvIII

Breast cancer/Brain metastases

NK-92/PB

scFv-CD28-CD3ζ

Lentivirus

[107]

2016

EGFR/EGFRvIII

Glioblastoma

PB

scFv-CD28-CD3ζ

Retrovirus

[108]

2021

EGFR/EGFRvIII

Breast cancer

PB

scFv-CD28-4-1BB-CD3ζ

Lentivirus

[109]

2020

GD2

Neuroblastoma

NK-92

scFv-CD3ζ

Retrovirus

[110]

2012

GD2

Ewing sarcomas

PB

scFv-4-1BB-2B4-CD3ζ

Retrovirus

[111]

2016

Mesothelin

Ovarian cancer

iPSC-NK cells/NK-92

scFv-NKG2D-2B4-CD3ζ

scFv-NKG2D-2B4-DAP10-CD3ζ

scFv-NKG2D-4-1BB-2B4-CD3ζ

Transposon transfection

[33]

2018

Mesothelin

Ovarian cancer

NK-92

scFv-CD28-4-1BB-CD3ζ

Lentivirus

[112]

2020

Mesothelin

gastric cancer

NK-92

scFv-NKG2D-2B4-CD3ζ

Lentivirus

[113]

2021

PSCA

Prostate cancer/Bladder carcinoma/Glioblastoma

NK cell line YTS

scFv-DAP12/scFv-CD3ζ

Lentivirus

[40]

2015

PSMA

Prostate cancer

NK-92

scFv-CD28-CD3ζ

Lentivirus

[114]

2020

PSMA

Prostate cancer

NK-92

scFv-NKG2D-2B4-CD3ζ

Lentivirus

[115]

2022

Glypican-3

Hepatocellular carcinoma

NK-92

scFv-CD28-CD3ζ

Lentivirus

[116]

2018

Glypican-3

Ovarian cancer

iPSC-NK

scFv-CD28-4-1BB-CD3ζ

Lentivirus

[117]

2020

Glypican-3

Hepatocellular carcinoma

NK-92

scFv-CD3ζ/scFv-CD28-CD3ζ/

scFv-DNAM1 or 2B4-CD3ζ

Lentivirus

[118]

2020

EpCAM

Breast carcinoma

NK-92

scFv-CD28-CD3ζ + IL-15

Lentivirus

[119]

2012

HLA-G

Solid tumor

PB

scFv-KIR2DS4-DAP12 + iCasp9

Lentivirus

[120]

2021

GPA7

Melanoma

NK-92

scFv-CD3ζ

mRNA electroporation

[121]

2017

c-MET

Hepatocellular carcinoma

PB

scFv-4-1BB-DAP12-EGFRt-V5

Lentivirus

[122]

2019

B7-H3

Non-small cell lung cancer

NK-92

scFv-4-1BB-CD3ζ

Lentivirus

[123]

2020

DLL3

Small cell lung cancer

NK-92

scFv-NKG2D-2B4-CD3ζ

Lentivirus

[124]

2022