Fig. 9From: Gut fungi enhances immunosuppressive function of myeloid-derived suppressor cells by activating PKM2-dependent glycolysis to promote colorectal tumorigenesis  A proposed model. C. tropicalis activates Syk through Dectin-3 receptor in MDSCs. Then activated p-Syk phosphorylates PKM2 Tyr 105, which results in nuclear translocation of PKM2. Subsequently, nuclear PKM2 interacts with HIF-1α and enhances the expression of HIF-1α target genes encoding glycolytic enzymes, GLUT1, HK2, PKM2, LDHA and PDK1, which in turn promotes aerobic glycolysis, immunosuppression of MDSCs and colorectal tumorigenesisBack to article page