Fig. 2

FOLR1 is a biomarker for LASC discrimination and correlated immune feature in LUSC. A Levels of the score of genes in the blue calculated by the ssGSEA method in LUAD (n = 512), LUSC (n = 430), and LASC (n = 66) subtypes. Significance was calculated with One-way ANOVA with Tukey’s multiple comparisons test. B Diagnostic value of the score of genes in the blue for the discrimination LASC in LUSC. C Diagnostic value of the single gene in the blue for the discrimination LASC in LUSC. D, E Representative images revealing FOLR1 expression in LUAD (n = 30) and LUSC (n = 90) subtypes and semi-quantitative analysis. Significance was calculated with Student’s t-test. F Prognostic value of FOLR1 expression in LUSC. Fifty-three patients with low FOLR1 expression, and 47 patients with high FOLR1 expression. Significance was calculated with log-rank test. G Representative images revealing low and high FOLR1 and PD-L1 expression in LUSC. H Correlation between FOLR1 and PD-L1 expression in LUSC. Significance was calculated with Pearson test. I Representative images revealing low and high FOLR1 and PD-L1 expression in LUAD. J Correlation between FOLR1 and PD-L1 expression in LUAD. Significance was calculated with Pearson test