Fig. 4
From: p53 amyloid aggregation in cancer: function, mechanism, and therapy
Strategies to recover p53 function in cancer therapy. (1) LI, ADH-6, ReACp53 can block p53 aggregation and prion-like behavior. (2) CDB3, CP31398 can stabilize p53 and restore the normal functionality. (3) Nutlins, MI series can interfere with the binding of p53-MDM2 and recover the function of p53. (4) Transfecting functional p53 via viruses to recover p53 function