Fig. 5

Lipid-binding proteins upregulated after induction therapy and changes in lipidomic profile. A UMAP of all analytes with apolipoproteins detected in the proteomics data highlighted. B Fold changes between detected apolipoproteins, with significantly increased (limma, adjusted p-value ≤ 0.05) apolipoproteins from diagnosis to post-induction indicated by (*). C Protein intensity of lipid binding proteins that were significantly increased at post-induction in PBP differential analysis. Bars indicate significant difference (limma, adjusted p-value ≤ 0.05) between the experimental conditions. D Classification of D29-enriched glycerophospholipids. E Comparison of the length and unsaturation levels of the triacylglycerols (TAGs) enriched at either diagnosis and post-induction