Fig. 8

Cholesterol absorption inhibitor inhibits cell viability of CLL cell lines. A, B CCK-8 assay and C, D apoptotic assay of circRIC8B-knockdown/overexpression and control cell lines of CLL with ezetimibe treatment at the indicated concentrations for 48 h (n = 3). E, F Expression of LPL mRNA and circRIC8B in cells treated with ezetimibe. G, H Expression change of LPL and circRIC8B after SD treatment. SD, serum deprivation. I Schematic diagram illustrated the circRIC8B regulating pathway in CLL and the possible mechanism underlying ezetimibe. circRIC8B promoted CLL progression by sponging miR-199b-5p and regulated LPL expression. Suppression of LPL by ezetimibe caused inversely induction of circRIC8B. Data are shown as means ± SD (n = 3, ns, no significant, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001)