Fig. 4

Clinical significance of biological functions of circRIC8B. A Kaplan–Meier plot analysed the association between circRIC8B expression level and overall survival. Log-rank tests were used to determine statistical significance (n = 63). B Comparison of TTT among patients with high or low levels of circRIC8B. C Expression levels of circRIC8B in patients with or without IGHV mutation. D Clinical characteristics of patients with CLL enrolled in this group. E, F circRIC8B expression in CLL cells transfected with circRIC8B overexpression plasmids or siRNAs by qRT-PCR. G, H Growth curves of cells measured by CCK-8 assay. N = 3 (mean ± SD); ^*P < 0.05, ^**P < 0.01 and ^***P < 0.001 by Student’s t‐test