Fig. 1
From: Next-generation sequencing for MRD monitoring in B-lineage malignancies: from bench to bedside
Summary of the allelic exclusion theory and the normal B cell differentiation process. A Heavy chain rearrangement precedes light chain rearrangement, and recombination of the IGK segment precedes IGL. SHM and CSR occur in GC after successful Ig rearrangement to produce mature BCR. B Maturation of B cells from hematopoietic stem cells to mature B cells with class-switched BCR (IgA/IgG) through Ig rearrangement and BCR signaling