From: Targeting metabolic reprogramming in chronic lymphocytic leukemia
Agents | Primary mechanism | Possible effects in CLL | Identifier |
---|---|---|---|
Statins | Competitive inhibitors of HMG-CoA reductase | Induces apoptosis of CLL cells | – |
Orlistat | LPL inhibitor | Induces apoptosis of CLL cells | – |
Idelalisib | Selective inhibitor of the lipid kinase PI3Kδ | Promotes apoptosis in primary CLL cells Disrupt interactions between CLL with endothelial cells and bone marrow stromal cells | NCT01539512 |
Ratonavir | GLUT4 inhibitor | Induces apoptosis | NCT02948283 |
L-asparaginase | Glutaminase inhibition | Catalyzes the conversion of glutamine to glutamate, especially in del11q CLL cells | – |
L-NAME | NOS inhibitors | Induces CLL cells apoptosis | – |
Berberine | Isoquinoline alkaloid | Inhibits CLL cell activation and eventual cell death | – |