Fig. 2
From: Targeting metabolic reprogramming in chronic lymphocytic leukemia
Aerobic glycolysis in CLL cells. A In normal cells, glucose is converted to pyruvate, which feeds the tricarboxylic acid (TCA) cycle for energy production under normoxia; B Pyruvate predominantly produces energy by lactic acid fermentation, even in the presence of oxygen (aerobic glycolysis) in cancer cells. The flux of pyruvate entering TCA cycle is decreased. C CLL cells do not follow the Warburg effect. They are not primarily dependent on glycolysis to produce energy, but increasing mitochondrial oxidative phosphorylation (OXPHOS). TCA tricarboxylic acid, OXPHOS oxidative phosphorylation