Fig. 2
From: Transfer RNA-derived small RNA: an emerging small non-coding RNA with key roles in cancer
Biological functions of tsRNAs. a tRF-3017A forms RICS with AGO to inhibit NELL2 expression. b i-tRFs decrease oncogenic transcript stability through competitive binding of YBX1. c tRF-3 inhibits HIV gene expression by binding to HIV-1 PBS with AGO2. d 5′ tsRNA inhibits the translation function of mRNAs of ribosomal proteins and translational factors through AGO2, which in turn affects global translation. e 5′ tiRNA assembles with eIF4E/G/A to form RG4 for translational inhibition. f tRF-3 enhances RPS28 mRNA translation by altering the secondary structure of mRNA. g 3′ tsRNA binding to Twi12 and Xrn2, Tan1 affects rRNA processing