Fig. 7

Long-term immunological effect of CML-RAE-1γ-Dex in vivo. Blank A and Blank B were inoculated with BP210 and BP210-T315I cells, respectively. a The maximum WBC count was recorded. b, c The weights of the liver (b) and spleen (c) in the four groups were measured. d Wright’s staining was carried out to examine leukemic cell infiltration in tissues. Microscopy images show the typical morphology of leukemic cells (arrows). Scale bar, 10 μm. e Tissue sections from the liver and spleen were stained H&E and showed infiltrated leukemic cells. Scale bar, 10 μm. f Cross-sectional microscopy images showing immunofluorescence staining were used to evaluate the BCR-ABL protein in bone marrow, spleen and liver tissues. Scale bar, 25 μm. g The Kaplan–Meier survival method was conducted to compare differences in survival among groups. **p < 0.01, ***p < 0.001