Fig. 8

Schematic diagram of the function and mechanisms of KW-2478 in CML cells. KW-2478 degrades BCR/ABL and downstream signalling proteins by inhibiting the binding of HSP90α and BCR/ABL. This molecule inhibits the growth of CML cells by inhibiting the MAPK signalling pathway. KW-2478 causes cytochrome C release and mitochondrial dysfunction to activate the caspase pathway and then induces apoptosis in CML cells