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Fig. 1 | Experimental Hematology & Oncology

Fig. 1

From: Generation and clinical potential of functional T lymphocytes from gene-edited pluripotent stem cells

Fig. 1

T lymphopoiesis in thymus. a HSC or embryonic non-HSC-derived TSP migrate into the CMJ, then differentiate into DN and DP cells, which are educated by different stromal cells (for example cTEC) in the cortex. DP cells mature into naïve conventional T cells and unconventional T cells in the presence of stromal cells (such as mTEC and DCs) in the medulla. b Different stages in T lymphopoiesis. A new cell atlas of human thymic development showed a unique pattern of T lymphopoiesis [31]: DN (early) → DN (P) → DN(Q) → DP(P) → DP(Q) → αβ T (entry), and new unconventional T subsets. Different TFs regulatory networks drive the formation of different stages and subsets. DN double negative T cells, DP double positive T cells, P proliferation, Q quiescent, HSC Hematopoietic stem cells, TSP thymus-seeding progenitors, CMJ cortico-medullary junction

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