Fig. 1

Chidamide and apatinib are synergistic to decrease the cell viability of CD34⁺CD38⁻ KG1α and Kasumi-1 cells. The CCK8 assay kit was used to determine the cell viability of both CD34⁺CD38⁻ KG1α (A) and Kasumi-1 cells (B) treated with the designated doses of apatinib (apa) and chidamide alone or in combinations for 48 h. C The combination index (CI) was calculated with the Chou-Talalay method based on the results described in A. The CI values of < 1, = 1, or > 1 indicate synergistic, additive, or antagonistic activity, respectively