Fig. 2

Donor and lineage distributions of CH clones and MDS clones. A Donor distributions of CH clones and MDS clones. Each column represents a donor. Each row represents a clone. The mutation composition per clone is shown on the far left. The presence of the clone in donors is shown as a yellow grid. Data of HD3 and HD5 were excluded since neither mutations nor clones were detected. B Comparison of the clone size between CH clones and MDS clones from the MDS group. C Comparison of the clone size of CH clones between the HD and MDS groups. D Comparison of the clone size among MDS clones marked with both CH mutations and MDS mutations (Double mutant clones), CH clones with the same CH mutations alone (CH mutant clones) and MDS clones with the same MDS mutations alone (MDS mutant clones) in eleven cases of four MDS patients. Clones from the same donors were connected with the line and shown in the same color. E Lineage distributions of CH clones and MDS clones. Each column represents one clone. The same clones were grouped under the same number. Clones not shared by two or more donors (Clones not shared) and clones shared by two or more donors (Clones shared) are separately shown. The presence of a clone in seven populations is shown as a yellow grid. The mutation composition per clone is shown on the bottom panel (see legends in part figure A). F Number of populations involved in CH clones and MDS clones. Each dot represents a clone. G Number of clones originating from HSCs and HPCs. (A-G) Mann–Whitney U test was used in all comparison analysis. ns, p > 0.05; **, p < 0.01; and ***, p < 0.001. Clones without any mutations and clones with uncertain mutations (NA) were excluded from these analyses