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Fig. 3 | Experimental Hematology & Oncology

Fig. 3

From: CD47xCD19 bispecific antibody triggers recruitment and activation of innate immune effector cells in a B-cell lymphoma xenograft model

Fig. 3

Both macrophages and NK cells are important effector cells for NI-1701 antitumor efficacy in Raji lymphoma xenograft model. a Design of the macrophage depletion experiment. b Tumor volume follow-up of CB17-SCID mice carrying Raji tumors treated with i.p. injection of NI-1701 and i.v. injection of clodronate liposomes. n = 5 mice per group. c Design of the NK cell depletion experiment. d Tumor volume follow-up of NOD SCID mice carrying Raji tumors treated with i.v. injection of NI-1701 and i.p. injection of anti-Asialo GM1 antibody. n = 8 mice per group. For b and d mean ± SEM is shown. Significance was determined at endpoint by one-way ANOVA test. *p < 0.05, ***p < 0.001, ****p < 0.0001

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