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Fig. 6 | Experimental Hematology & Oncology

Fig. 6

From: The GPIb-IX complex on platelets: insight into its novel physiological functions affecting immune surveillance, hepatic thrombopoietin generation, platelet clearance and its relevance for cancer development and metastasis

Fig. 6

Multiple roles of GPIb-IX in immune modulation. GPIb-IX regulates NET formation, bacteria shuttling to the Kupffer cells and uptake by dendritic cells, and is involved in bacteria encasement. GPIb-IX regulates thrombin activity at sites of immune thrombosis, initiates macrophage polarization towards an M1 phenotype, and supports monocyte recruitment to inflammatory endothelial cells. GPIb-IX regulates leukocyte recruitment to the central nervous system which contribute to severity of autoimmune encephalomyelitis

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Experimental Hematology & Oncology

ISSN: 2162-3619

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