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Fig. 3 | Experimental Hematology & Oncology

Fig. 3

From: The GPIb-IX complex on platelets: insight into its novel physiological functions affecting immune surveillance, hepatic thrombopoietin generation, platelet clearance and its relevance for cancer development and metastasis

Fig. 3

Mechanoreceptor domains in GPIb. GPIbα contains two mechanosensitive domains (MSD), which support each other in signal transduction. The first domain is located in the leucine-rich repeat domain (LRRD) and the second one is between the macroglycopeptide domain and the trigger sequence. Upon VWF binding and pulling, both domains are unfolded and induce a cooperation for intracellular Ca2+ release, Rac1, LIMK, and platelet activation

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Experimental Hematology & Oncology

ISSN: 2162-3619

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