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Fig. 2 | Experimental Hematology & Oncology

Fig. 2

From: The GPIb-IX complex on platelets: insight into its novel physiological functions affecting immune surveillance, hepatic thrombopoietin generation, platelet clearance and its relevance for cancer development and metastasis

Fig. 2

GPIb-IX and protease-activated receptor-1 (PAR-1) signaling cooperation. GPIbα and PAR-1 reveal a mutual dependence for platelet activation by low thrombin concentrations. For full platelet activation, PAR-1 signaling and simultaneously a GPIb-IX–specific 14-3-3–Rac1–LIMK1 signaling pathway activation are required

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Experimental Hematology & Oncology

ISSN: 2162-3619

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