Table 1 Selected putative IRE1 substrates
Gene symbol | FC | Function |
|---|---|---|
ATM | − 34.9 | Regulation of DNA damage response |
VPS13C | − 15.96 | Regulation of mitocondrial function |
BIRC6 | − 12.04 | Ubiquitination and proteosomal protein involved in ubiquitin activity |
KMT2C | − 9.94 | Protein methylation |
HUWE1 | − 7.91 | Ubiquitination and proteosomal protein involved in ubiquitin activity |
RICTOR | − 6.79 | TOR signaling |
CDK12 | − 6.55 | Cyclin dependent kinase 12 |
CENPF | − 6.03 | Cell cycle regulation and apoptosis induction |
VPS13D | − 6.01 | Membrane trafficking |
GOLGB1 | − 6.00 | Golgi to plasma membrane transport |
FAM168B | − 5.81 | Inhibitor |
ATR | − 5.60 | Regualtion of DNA damage response |
AKAP9 | − 5.34 | Cell cycle regulation and apoptosis induction |
NOTCH1 | − 4.86 | Transcription factors (Cell fate determination, proliferation, differentiation, apoptosis) |
PCM1 | − 3.84 | Cell cycle regulation and apoptosis induction |
UBR2 | − 3.60 | Ubiquitination and proteosomal protein involved in ubiquitin activity |
KLF13 | − 3.44 | Transcription factors (Cell fate determination, proliferation, differentiation, apoptosis) |
mTOR | − 3.03 | TOR signaling |
DICER | − 2.99 | Ribonuclease III activity |
XRN1 | − 2.90 | Regualtion of DNA damage response |
CUL9 | − 2.81 | Ubiquitination and proteosomal protein involved in ubiquitin activity |
UBE4B | − 2.68 | Ubiquitination and proteosomal protein involved in ubiquitin activity |
PSME4 | − 2.47 | Ubiquitination and proteosomal protein involved in ubiquitin activity |
CUL4B | − 2.36 | Ubiquitination and proteosomal protein involved in ubiquitin activity |
UBR3 | − 2.35 | Ubiquitination and proteosomal protein involved in ubiquitin activity |
UBA6 | − 2.33 | Ubiquitination and proteosomal protein involved in ubiquitin activity |
IKZF1 | − 2.28 | Transcription factors (Cell fate determination, proliferation, differentiation, apoptosis) |
PSMD1 | − 2.24 | Ubiquitination and proteosomal protein involved in ubiquitin activity |
CUL5 | − 2.05 | Ubiquitination and proteosomal protein involved in ubiquitin activity |
ERAP1 | − 2.00 | Protein processing and transport. Cleaves other proteins into smaller fragments |
PRDM1 | − 1.71 | Transcription factor implicated in the differentiation of PC |
IRF4 | − 1.59 | Transcription factor implicated in the differentiation of PC |