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Fig. 4 | Experimental Hematology & Oncology

Fig. 4

From: RNA sequencing identifies novel regulated IRE1-dependent decay targets that affect multiple myeloma survival and proliferation

Fig. 4

Mapping the cleavage site of IRE1 targets. A mRNA sequence around the consensus sequence of the newly identified IRE1 targets. The consensus sequence is underlined. The numbers indicate the guanine position at the consensus sequence, where IRE1 is supposed to cleave. B Schematic representation of the secondary mRNA structures containing the consensus sequence of the identified targets of IRE1. C mRNA levels of the indicated genes in H929 determined by qRT-PCR. cDNAs were obtained from mRNAs cleaved by IRE1 or mock treatment samples (control, C) and synthesized with oligo (dT) and primers mapping the predicted cleavage site. All results are presented as the means ± SD of three experiments. (*p < 0.05, **p < 0.01, ***p < 0.001)

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Experimental Hematology & Oncology

ISSN: 2162-3619

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