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Table 2 The targets of YTHDF2 and their functions in cancers

From: m6A binding protein YTHDF2 in cancer

Cancer type

Target

Gene description

Role

References

GC

PTEN

Phosphate and tension homology deleted on chromosome ten

Tumor suppressor

[39]

FOXC2

Forkhead box protein C2

Oncogene

[46]

CRC

miR-1625

microRNA 6125

Tumor suppressor

[49]

GSK3β

Glycogen synthase kinase 3 beta

Tumor suppressor

[49]

XIST

X inactivate-specific transcript

Oncogene

[47]

Liver cancer

miR-145

microRNA 145

Tumor suppressor

[55]

SOCS2

Suppressor of cytokine signaling 2

Tumor suppressor

[54]

OCT4 (POU5F1)

POU class 5 homeobox 1

Oncogene

[53]

EGFR

Epidermal growth factor receptor

Oncogene

[36]

Serpin E2

Serpin peptidase inhibitor clade E member 2

Oncogene

[50]

IL11

Interleukin-11

Oncogene

[50]

PC

YAP

YES-associated protein

Oncogene

[56]

PER1

Period circadian regulator 1

Tumor suppressor

[58]

PIK3CB

Phosphoinositide-3-kinase catalytic beta

Oncogene

[57]

Lung cancer

6PGD

6-phosphogluconate dehydrogenase

Oncogene

[40]

AXIN1

axin 1

Tumor suppressor

[62]

Leukemia

TNFRSF1B

TNF receptor superfamily member 1b

Tumor suppressor

[38]

PCa

LHPP

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Tumor suppressor

[66]

NKX3–1

NK3 homeobox 1

Tumor suppressor

[66]

miR-495

microRNA 495

Tumor suppressor

[67]

MOB3B

MOB kinase activator 3B

Tumor suppressor

[67]

Bladder cancer

SETD7

SET domain containing 7

Tumor suppressor

[65]

KLF4

Kruppel like factor 4

Tumor suppressor

[65]

CC

GAS5

Growth arrest specific 5

Tumor suppressor

[73]

Ovarian cancer

BMF

Bcl2 modifying factor

Tumor suppressor

[72]

Breast cancer

PRSS23

Serine protease 23

Tumor suppressor

[71]

Osteosarcoma

PVT1

Plasmacytoma variant translocation 1

Oncogene

[41]

Melanoma

TP53

Tumor protein P53

Tumor suppressor

[75]

PD-1

Programmed death 1

Oncogene

[31]

CXCR4

C-X-C motif chemokine receptor 4

Oncogene

[31]

SOX10

SRY-Box Transcription Factor 10

Oncogene

[31]

GBM

MYC

MYC proto-oncogene

Oncogene

[76]

VEGFA

Vascular endothelial growth factor A

Oncogene

[76]

LXRA

Liver X receptors A

Tumor suppressor

[77]

HIVEP2

HIVEP Zinc Finger 2

Tumor suppressor

[77]

UBXN1

UBX domain protein 1

Tumor suppressor

[78]

  1. GC Gastric cancer, CRC Colorectal cancer, PC Pancreatic cancer, PCa  Prostate cancer, CC Cervical cancer, GBM Glioblastoma