m6A binding protein YTHDF2 in cancer

Chen, Xiaomin; Zhou, Xiangxiang; Wang, Xin

doi:10.1186/s40164-022-00269-y

Experimental Hematology & Oncology

Table 2 The targets of YTHDF2 and their functions in cancers

From: m⁶A binding protein YTHDF2 in cancer

Cancer type	Target	Gene description	Role	References
GC	PTEN	Phosphate and tension homology deleted on chromosome ten	Tumor suppressor	[39]
GC	FOXC2	Forkhead box protein C2	Oncogene	[46]
CRC	miR-1625	microRNA 6125	Tumor suppressor	[49]
	GSK3β	Glycogen synthase kinase 3 beta	Tumor suppressor	[49]
	XIST	X inactivate-specific transcript	Oncogene	[47]
Liver cancer	miR-145	microRNA 145	Tumor suppressor	[55]
	SOCS2	Suppressor of cytokine signaling 2	Tumor suppressor	[54]
	OCT4 (POU5F1)	POU class 5 homeobox 1	Oncogene	[53]
	EGFR	Epidermal growth factor receptor	Oncogene	[36]
	Serpin E2	Serpin peptidase inhibitor clade E member 2	Oncogene	[50]
	IL11	Interleukin-11	Oncogene	[50]
PC	YAP	YES-associated protein	Oncogene	[56]
	PER1	Period circadian regulator 1	Tumor suppressor	[58]
	PIK3CB	Phosphoinositide-3-kinase catalytic beta	Oncogene	[57]
Lung cancer	6PGD	6-phosphogluconate dehydrogenase	Oncogene	[40]
Lung cancer	AXIN1	axin 1	Tumor suppressor	[62]
Leukemia	TNFRSF1B	TNF receptor superfamily member 1b	Tumor suppressor	[38]
PCa	LHPP	Phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Tumor suppressor	[66]
	NKX3–1	NK3 homeobox 1	Tumor suppressor	[66]
	miR-495	microRNA 495	Tumor suppressor	[67]
	MOB3B	MOB kinase activator 3B	Tumor suppressor	[67]
Bladder cancer	SETD7	SET domain containing 7	Tumor suppressor	[65]
Bladder cancer	KLF4	Kruppel like factor 4	Tumor suppressor	[65]
CC	GAS5	Growth arrest specific 5	Tumor suppressor	[73]
Ovarian cancer	BMF	Bcl2 modifying factor	Tumor suppressor	[72]
Breast cancer	PRSS23	Serine protease 23	Tumor suppressor	[71]
Osteosarcoma	PVT1	Plasmacytoma variant translocation 1	Oncogene	[41]
Melanoma	TP53	Tumor protein P53	Tumor suppressor	[75]
	PD-1	Programmed death 1	Oncogene	[31]
	CXCR4	C-X-C motif chemokine receptor 4	Oncogene	[31]
	SOX10	SRY-Box Transcription Factor 10	Oncogene	[31]
GBM	MYC	MYC proto-oncogene	Oncogene	[76]
	VEGFA	Vascular endothelial growth factor A	Oncogene	[76]
	LXRA	Liver X receptors A	Tumor suppressor	[77]
	HIVEP2	HIVEP Zinc Finger 2	Tumor suppressor	[77]
	UBXN1	UBX domain protein 1	Tumor suppressor	[78]

GC Gastric cancer, CRC Colorectal cancer, PC Pancreatic cancer, PCa Prostate cancer, CC Cervical cancer, GBM Glioblastoma

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ISSN: 2162-3619

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