Fig. 4
Roles of YTHDF2 in inhibition of cancer progression. YTHDF2 plays an essential role in tumor proliferation, invasion, migration, and metastasis. The fundamental mechanisms are shown as follow: A the PI3K/AKT signaling pathway, B the MAPK/ERK pathway, C Hippo/YAP pathway, D the inflammatory pathway, E YTHDF2 regulates the degradation of oncogenes in an m6A-dependent manner, F YTHDF2 directly interacts with YAP to enhance its degradation