Fig. 3
The underlying mechanisms of YTHDF2 in promoting cancer progression. YTHDF2 plays a significant role in tumor proliferation, invasion, migration, metabolism, and apoptosis in an m6A-dependent manner. The fundamental mechanisms are shown as follow: A the pentose phosphate pathway, B tumor necrosis factor (TNF) signaling, C the PI3K/AKT signaling pathway, D Wnt/β-catenin pathway, E miRNAs modulate YTHDF2 expression, F YTHDF2 modulates the expression of tumor suppressors in an m6A-dependent manner