Fig. 2
Two hypotheses of YTHDF2 structure. A Eight β-strands (β1-β8), three α-helices (α1-α3) and two 310-helices in YTHDF2 domain, with W486, W432, and W491 form an aromatic cage containing m6A mononucleotides. B The structure of the YTH domain contains four β-sheets (β1–β4), four α-helices (α1–α4), and flanking regions on both sides. The aromatic residues Y418, W432, W486, and W491 form a hydrophobic pocket