Fig. 1

The schematic of m⁶A modification mechanism. METTL3 and METTL14 shape the m⁶A methyltransferase complex along with WTAP, VIRMA, KIAA1429, RBM15/15b, ZC3H13, and HAKAI, serving as m⁶A "writers". FTO and ALKBH5 shape the m⁶A demethylase, serving as m⁶A "erasers". YTHDF1/2/3, eIF3, IGF2BP1/2/3, and HNRNPs shape the m⁶A modification binding protein, serving as m⁶A “readers”