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Table 3 Risk factors for overall survival in univariate and multivariate analysis

From: Distinct outcomes, ABL1 mutation profile, and transcriptome features between p190 and p210 transcripts in adult Philadelphia-positive acute lymphoblastic leukemia in the TKI era

Variable Univariate analysis Multivariate analysis
HR 95% CI p-value HR 95% CI p-value
Age [≥35/ <35 (years)] 1.077 0.553–2.100 0.827
WBC count [≥ 30/ < 30 (*10E9/L)] 1.949 1.162–3.269 0.011 1.823 1.082–3.072 0.024
PLT count [<30/ ≥30 (*10E9/L)] 1.154 0.690–1.932 0.585
Cytogenetics (with ACAs/without ACAs) 0.966 0.540–1.729 0.909
BCR–ABL1 transcript (p210/p190) 1.833 1.099–3.057 0.020 1.692 1.082–2.838 0.046
Initial TKIs administrating (2nd/1st) 0.675 0.331–1.376 0.279
CNS involvement (yes/no) 1.284 0.546–3.022 0.567
  1. WBC white blood cell, PLT platelet, ACAs additional cytogenetic abnormalities, CNS central nervous system, TKIs tyrosine kinase inhibitors, HR hazard ratio, CI confidence interval