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Table 3 Risk factors for overall survival in univariate and multivariate analysis

From: Distinct outcomes, ABL1 mutation profile, and transcriptome features between p190 and p210 transcripts in adult Philadelphia-positive acute lymphoblastic leukemia in the TKI era

Variable

Univariate analysis

Multivariate analysis

HR

95% CI

p-value

HR

95% CI

p-value

Age [≥35/ <35 (years)]

1.077

0.553–2.100

0.827

–

–

–

WBC count [≥ 30/ < 30 (*10E9/L)]

1.949

1.162–3.269

0.011

1.823

1.082–3.072

0.024

PLT count [<30/ ≥30 (*10E9/L)]

1.154

0.690–1.932

0.585

–

–

–

Cytogenetics (with ACAs/without ACAs)

0.966

0.540–1.729

0.909

–

–

–

BCR–ABL1 transcript (p210/p190)

1.833

1.099–3.057

0.020

1.692

1.082–2.838

0.046

Initial TKIs administrating (2nd/1st)

0.675

0.331–1.376

0.279

–

–

–

CNS involvement (yes/no)

1.284

0.546–3.022

0.567

–

–

–

  1. WBC white blood cell, PLT platelet, ACAs additional cytogenetic abnormalities, CNS central nervous system, TKIs tyrosine kinase inhibitors, HR hazard ratio, CI confidence interval