Fa | ALMC-2 | JJN3 | MM.1S | RPMI |
---|
0.3 | 1.81 | 1.22 | 1.45 | 1.36 |
0.5 | 1.95 | 1.25 | 1.5 | 1.37 |
0.75 | 2.2 | 1.35 | 1.58 | 1.38 |
- Cells were incubated with varying concentrations of RAM2061 and/or bortezomib. RAM2061 and bortezomib were added at the beginning of the 48-h incubation period (concurrent). Isobologram analysis was performed, and combination indices were determined. Combination indices > 1 are considered antagonistic in nature