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Fig. 6 | Experimental Hematology & Oncology

Fig. 6

From: Tanshinone IIA attenuates the stemness of breast cancer cells via targeting the miR-125b/STARD13 axis

Fig. 6

Tanshinone IIA attenuates breast cancer stemness partly dependent on miR-125b/STARD13 axis. A, B Breast cancer cells treated with Tanshinone IIA (10 μM) plus miR-125b overexpression or STARD13 knockdown and then subjected to qRT-PCR assay to examine stemness markers (Oct4 and ALDH1A1) mRNA levels. C Stemness markers (Oct3/4 and ALDH1A1) protein levels were evaluated in A-depicted cells. D, E Spheroid formation capacity was evaluated in A-depicted cells. F Representative FACS profile of A-depicted cells were denoted with CD24− and CD44+ markers. G ALDH activity was measured in cells depicted in A. n = 3, **p < 0.01 vs. Control, ##p < 0. 01 vs. Tanshinone IIA. For transfection experiments, control groups were transfected with NC

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