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Fig. 2 | Experimental Hematology & Oncology

Fig. 2

From: Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies

Fig. 2

The effects of TAMs on tumor progression. The schematic diagram shows that TAMs promote tumorigenesis, angiogenesis, invasion, metastasis, epithelial-mesenchymal transformation (EMT) and the acquisition of stem cell characteristics. TAMs suppress the immune response through secretion of certain factors or proteases. TAMs tumor-associated macrophages, IL-6 interleukin-6, IL-17 interleukin-17, IFN-γ Interferon-γ, VEGF vascular endothelial growth factor, Ang angiotensin, IL-10 interleukin-10, CCL17 C–C chemokine ligand 17, IDO 1/2 indoleamine 2,3-dioxygenase 1/2, PD-L1, programmed cell death ligand 1, CTLs CD8+ cytotoxic T lymphocytes, CSCs cancer stem cells, MMPs metalloproteinases, CSF-1 colony-stimulating factor-1, EMT epithelial mesenchymal transformation, SIRP α signal-regulatory protein α, MMP2/3/7/9 metalloproteinase 2/3/7/9

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