Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy

Table 3 Nonspecific diagnostic criteria for HSCT-TMA

Parameter	Blood and Marrow Transplant Clinical Trials Network (2005) [37]	International Working Group (2007) [38]	Overall TMA grouping (2010) [39]	City of Hope (2013) [40]	American Society of Hematology–European Society for Blood and Marrow Transplantation (2014) [41]	Jodele criteria (2014) [29] Pediatric
Schistocytes	√	√	√	√	√	√
Elevated LDH	√	√	√	√	√	√
Thrombocytopenia		√	√	√	√	√
Decreased hemoglobin		√	√		√	√
Negative Coombs test	√		√		√
Increased serum creatinine	√			√
Decreased haptoglobin		√	√
Elevated soluble C5b-9					√	√
Proteinuria					√	√
Hypertension					√	√
Other	Neurologic dysfunction				TA-TMA Index ≥ 20

LDH Lactate dehydrogenase, HSCT-TMA Hematopoietic stem cell transplantation-associated thrombotic microangiopathy, TA-TMA Transplant-associated thrombotic microangiopathy, TMA Thrombotic microangiopathy
√ = presence of parameter in HSCT-TMA diagnostic criteria

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