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Table 3 Nonspecific diagnostic criteria for HSCT-TMA

From: Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy

Parameter Blood and Marrow Transplant Clinical Trials Network (2005) [37] International Working Group (2007) [38] Overall TMA grouping (2010) [39] City of Hope (2013) [40] American Society of Hematology–European Society for Blood and Marrow Transplantation (2014) [41] Jodele criteria (2014) [29]
Elevated LDH
Decreased hemoglobin   
Negative Coombs test    
Increased serum creatinine     
Decreased haptoglobin     
Elevated soluble C5b-9     
Other Neurologic dysfunction     TA-TMA Index ≥ 20  
  1. LDH Lactate dehydrogenase, HSCT-TMA Hematopoietic stem cell transplantation-associated thrombotic microangiopathy, TA-TMA Transplant-associated thrombotic microangiopathy, TMA Thrombotic microangiopathy
  2. √ = presence of parameter in HSCT-TMA diagnostic criteria